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Opioid reduction done badly has real and devastating consequences, with a risk of mental health crisis, opioid overdose (particularly from non-prescribed opioids), and suicide For some patients …
Nov 20, 2024 · The rationale underpinning opioid rotation is that of ‘incomplete cross-tolerance’ (i.e. a high level of tolerance to one opioid may not be demonstrated with an alternative one) [48]
The guideline for opioid rotation uses existing equianalgesic dose tables as a reasonable starting point, though it is difficult to predict whether an individual patient will react to an opioid switch as …
They therefore do not reflect complex and heterogeneous clinical situations. 13 When performing an opioid rotation, it is recommended to reduce the calculated equianalgesic dose by 30–50% …
Opioid rotation refers to a switch from one opioid to another in an effort to improve the response to analgesic therapy or reduce adverse effects. It is a common method to address the problem of …
To account for incomplete cross-tolerance, we further reduce the calculated dose by 30%. Results The majority of patients had mixed nociceptive-neuropathic pain (83%) and the predominant …
Although the specific mechanisms by which opioid rotation improves the overall response totherapyarenotknown,thetheoreticalbasisre-lates broadly tothe large individualvariationthat …
Sep 1, 2009 · Although the specific mechanisms by which opioid rotation improves the overall response to therapy are not known, the theoretical basis relates broadly to the large individual …
The clinical advantage of opioid rotation lies in the possibility of incomplete cross-tolerance favouring analgesia more than adverse effects. The disadvantage is that the clinician cannot …
Apr 1, 2005 · Opioid rotation without reducing the calculated dose to account for incomplete analgesic cross-tolerance may cause increased side effects such as hallucinations, respiratory …
Aug 1, 2015 · There is increasing evidence that incomplete cross-tolerance between methadone and other strong opioids means that lower equianalgesic doses of methadone than those published in …
Nov 7, 2024 · ALL OPIOID CONVERSIONS OUTLINED BELOW ARE APPROXIMATE ONLY Allow for the phenomenon of incomplete cross tolerance and reduce the calculated dose by 25% - 50% …
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